Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial

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• 作者：Ju Qiu^a ; ¹ ; Yanping Liu^b ; ¹ ; Yanfen Yue^c ; Yuchang Qin^a ; Zaigui Li^d ; ^{lizg@cau.edu.cn}
• 关键词：BMI ; body mass index ; CB ; common buckwheat ; DC ; diet control ; HbA1c ; glycated hemoglobin ; HDL-c ; high-density lipoprotein cholesterol ; HOMA-IR ; homeostasis model assessment of insulin resistance ; LDL-c ; low-density lipoprotein cholesterol ; MetS ; metabolic syndrome ; T2DM ; Type 2 diabetes mellitus ; TB ; Tatary buckwheat ; TC ; total cholesterol ; TG ; triglycerides ; WF ; white wheat flour ; WR ; white rice
• 刊名：Nutrition Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：36
• 期：12
• 页码：1392-1401
• 全文大小：357 K
• 卷排序：36

文摘

Tartary buckwheat (TB) is rich in protein, dietary fiber, and flavonoids and has been reported to affect type 2 diabetes mellitus (T2DM) in animal experiments, but limited information on the benefit of TB as a whole food in T2DM patients is available. Thus, we tested the hypothesis that a daily replacement of a portion of the staple food with TB will improve risk factors of T2DM, including fasting glucose, insulin resistance, and lipid profile. In a parallel, randomized, open-label, controlled trial, 165 T2DM patients were randomly assigned to a control diet group (DC group; systematic diet plans and intensive nutritional education) or a TB intervention group (TB group; daily replacement of a portion of staple food with TB food). Blood samples and diet information were collected at baseline and after 4 weeks of intervention. The TB group decreased fasting insulin (2.46-2.39 Ln mU/L), total cholesterol (5.08-4.79 mmol/L), and low-density lipoprotein cholesterol (3.00-2.80 mmol/L) compared with the DC group at 4 weeks (P < .05). No significant differences in blood glucose or glycated hemoglobin levels were noted between the TB and DC groups. In addition, subgroup analyses based on daily TB intake dose showed a reduction in insulin, total cholesterol, and low-density lipoprotein cholesterol, but also insulin resistance was observed when TB intake dose was greater than 110 g/d. These results support the hypothesis that TB may improve insulin resistance and lipid profile in T2DM patients.