Tetracycline-inducible shRNA targeting antisense long non-coding RNA HIF1A-AS2 represses the malignant phenotypes of bladder cancer
详细信息 查看全文
- 作者：Mingwei Chena ; b ; c ; 1 ; Chengle Zhuanga ; d ; 1 ; Yuchen Liua ; 1 ; Jianfa Lia ; d ; 1 ; Fen Daic ; Ming Xiae ; Yonghao Zhana ; d ; Junhao Lina ; d ; Zhicong Chena ; d ; Anbang Hea ; c ; Wen Xua ; Guoping Zhaoa ; f ; Yinglu Guog ; Zhiming Caia ; c ; d ; g ; caizhiming2000@163.com" class="auth_mail" title="E-mail the corresponding author ; Weiren Huanga ; c ; d ; g ; pony8980@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HIF1A-AS2 ; Bladder cancer ; LncRNAs ; Tetracycline-inducible ; Synthetic biology
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：376
- 期：1
- 页码：155-164
- 全文大小：4618 K
文摘
- •
HIF1A-AS2 was up-regulated as oncogene in bladder cancer.
- •
“Tet-on” shRNA switch quantitatively silenced HIF1A-AS2 and suppressed bladder cancer progression as an amplifier by dosage-dependent manner.
- •
It is a therapeutic method for bladder cancer.