Inclusion complexes of HP-β-cyclodextrin with agomelatine: Preparation, characterization, mechanism study and in vivo evaluation
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- 作者：Yunhui Liao ; Xuefei Zhang ; Chenglin Li ; Yanjuan Huang ; Ming Lei ; Mina Yan ; Yuefang Zhou ; Chunshun Zhao ; zhaocs@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hydroxypropyl-β-cyclodextrin inclusion complex ; Agomelatine ; Inclusion mechanism ; Molecular modeling studies ; Absorption ; Pharmacokinetics
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 August 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：415-425
- 全文大小：1546 K
文摘
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AGM/HPβ-CD inclusion complexes was prepared successfully by freeze-drying.
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The inclusion mechanism was evaluated by variety of methods including 1H NMR and molecular modeling.
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The oral bioavailability of AGM was significantly enhanced by inclusion technology.