c-Jun N-terminal kinase (JNK) is involved in immune defense against bacterial infection in Crassostrea hongkongensis
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- 作者：Fufa Qu<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>csup> ; Zhiming Xiang<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>zhimingxiang@scsio.ac.cnsup> ; Shu Xiao<sup>asup><sup> ; sup><sup>bsup> ; Fuxuan Wang<sup>asup><sup> ; sup><sup>bsup> ; Jun Li<sup>asup><sup> ; sup><sup>bsup> ; Yang Zhang<sup>asup><sup> ; sup><sup>bsup> ; Yuehuan Zhang<sup>asup><sup> ; sup><sup>bsup> ; Yanping Qin<sup>asup><sup> ; sup><sup>bsup> ; Ziniu Yu<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>carlzyu@scsio.ac.cnsup>
- 关键词：c-Jun N-terminal kinase ; Molecular characteristics ; Expression analysis ; Bacterial challenge ; C. hongkongensis
- 刊名：Developmental & Comparative Immunology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：67
- 期：Complete
- 页码：77-85
- 全文大小：3467 K
- 卷排序：67
文摘
The first experimental evidence for presence of a functional JNK in Crassostrea hongkongensis. ChJNK transcripts were broadly expressed in various tissues and developmental stages. ChJNK expression was increased significantly in response to bacterial infections. ChJNK was localized to the cytoplasm and its overexpression could activate AP-1-Luc in HEK293T cells.