Cdx2 represses Oct4 function via inducing its proteasome-dependent degradation in early porcine embryos
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- 作者：Gerelchimeg Bou1 ; Shichao Liu1 ; Jia Guo ; Yueming Zhao ; Mingju Sun ; Binghua Xue ; Jiaqiang Wang ; Yanchang Wei ; Qingran Kong ; Zhonghua Liu ; liu086@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pig ; Early embryo ; Cdx2 ; Oct4 ; Molecular interaction ; Proteasomal degradation
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：410
- 期：1
- 页码：36-44
- 全文大小：4740 K
文摘
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Over-expression of Cdx2 in early porcine embryo showed CDX2 represses Oct4 through neither the transcriptional repression nor forming repressive complex.
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Over-expression of Cdx2 in early porcine embryo promotes OCT4 nuclear export and proteasomal degradation.
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It revealed a new mechanism of interaction between CDX2 and Oct4 in mammalian embryo.