Podocarpane, isopimarane, and abietane diterpenoids from Isodon lophanthoides var. graciliflorus

详细信息    查看全文

• 作者：Yaoguang Liang ; Haihui Xie ; ^{xiehaih@scbg.ac.cn} ; Ping Wu ; Yueming Jiang ; Xiaoyi Wei
• 关键词：Isodon lophanthoides var. graciliflorus ; Podocarpane ; Isopimarane acetal ; Abietane ; Cytotoxicity
• 刊名：Food Chemistry
• 出版年：2013
• 出版时间：15 February, 2013
• 年：2013
• 卷：136
• 期：3-4
• 页码：1177-1182
• 全文大小：337 K

文摘

Four new diterpenoids including two podocarpanes, graciliflorins A (1) and B (2), an isopimarane acetal, graciliflorin C (3), and a rearranged abietane, graciliflorin D (4) were isolated from the aerial parts of Isodon lophanthoides var. graciliflorus (Lamiaceae) along with podocarpa-8,11,13-triene-3¦Á,13-diol (5) and micranthin B (6). Their structures were elucidated based on the spectroscopic data. The in vitro cytotoxicity of compounds 1-4 and 6 against human carcinoma A549, MCF-7, and HeLa cell lines were evaluated using the MTT colourimetric assay. Micranthin B (6) showed moderate activity against all the cells with IC₅₀ values of 16.29, 18.20, and 22.25 ¦ÌM, while compounds 1-4 were inactive (IC₅₀ > 50 ¦Ìg/ml).