Imidazolium carboxylate ILs were used to evaluate hydrotropy effect on rutin.
[C4bim][Pro] was chosen to extract and separate FSI flavonoids with aid of ILABS.
The optimum separation conditions of ILABS was obtained by RSM.
Flavonoids in the IL-rich phase was recovered with only water as anti-solvent.
Extracts from the combined process showed obvious radical-scavenging ability.