PEGylated polyethylenimine-entrapped gold nanoparticles modified with folic acid for targeted tumor CT imaging
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- 作者：Benqing Zhoua ; 1 ; Jia Yangb ; 1 ; Chen Pengc ; Jianzhi Zhua ; Yueqin Tangd ; Xiaoyue Zhua ; Mingwu Shena ; Guixiang Zhangb ; guixinagzhang@sina.com" class="auth_mail" title="E-mail the corresponding author ; Xiangyang Shia ; c ; e ; xshi@dhu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Polyethyleneimine ; Folic acid ; Gold nanoparticles ; Tumors ; CT imaging
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：489-496
- 全文大小：2667 K
文摘
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PEGylated PEI can be used as a template for the synthesis of AuNPs.
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The FA-Au PENPs are water soluble, stable, and cytocompatible in a given concentration range.
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The FA-Au PENPs are able to target cancer cells overexpressing FA receptors.
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The FA-Au PENPs can be used as a nanoprobe for targeted tumor CT imaging.