IL-17 protein levels in both induced sputum and plasma are increased in stable but not acute asthma individuals with obesity

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• 作者：Jian-Hui Chen^a ; ^b ; ^{1284530031@qq.com} ; Ling Qin^a ; ^{15152368813@163.com} ; Ying-Ying Shi^c ; ^{shiyingying82012@163.com} ; Jun-Tao Feng^a ; ^{513204423@qq.com} ; Yu-Long Zheng^b ; ^{ha183@163.com} ; Yu-Feng Wan^b ; ^{ggwanyufeng@163.com} ; Chuan-Qin Xu^b ; ^{657442476@qq.com} ; Xiao-Mei Yang^b ; ^{ha315@163.com} ; Cheng-Ping Hu^a ; ^{cjh0517@sohu.com}
• 关键词：Asthma ; Depression ; Exacerbation ; IL-17 ; Neutrophils ; Obesity
• 刊名：Respiratory Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：121
• 期：Complete
• 页码：48-58
• 全文大小：2103 K
• 卷排序：121

文摘

Sputum and plasma levels of IL-17 are increased in stable asthmatics with obesity. Raised sputum IL-17 contributes to airway neutrophilia in obese stable asthmatics. Higher plasma IL-17 correlates positively with depressive symptoms in stable asthma. Obesity may not adversely influence the severity of an asthma exacerbation. IL-17 expression is increased and plays a role in acute asthma.