Negative effects of retinoic acid on stem cell niche of mouse incisor

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• 作者：Jinlei Xi^b ; Shijing He^a ; Cizhao Wei^a ; Wanyao Shen^a ; Juan Liu^b ; Ke Li^a ; Yufeng Zhang^c ; Jiang Yue^a ; Zheqiong Yang^a ; ^{zheqiong_yang@whu.edu.cn}
• 关键词：Stem cell ; Tooth ; Retinoic acid ; Apoptosis ; Proliferation ; Fgf10
• 刊名：Stem Cell Research
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：17
• 期：3
• 页码：489-497
• 全文大小：1953 K
• 卷排序：17

文摘

Exogenous retinoic acid (RA) shows negative effects on incisor stem cells (SCs). RA induces apoptosis and inhibits proliferation in incisor SCs. RA effects on incisor SCs are mediated by downregulation of mesenchymal Fgf10. RA signaling is subject to a negative feedback regulation in developing incisor.