Dual role of vinculin in barrier-disruptive and barrier-enhancing endothelial cell responses
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- 作者：Anna A. Birukova ; Alok S. Shah ; Yufeng Tian ; Nurgul Moldobaeva ; Konstantin G. Birukov ; kbirukov@medicine.bsd.uchicago.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AJ ; adherens junctions ; EC ; endothelial cells ; FA ; focal adhesions ; GEF ; guanine nucleotide exchange factor ; HPAEC ; human pulmonary artery endothelial cells ; MLC ; myosin light chain ; MYPT1 ; myosin light chain phosphatase ; OxPAPC ; Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine ; TER ; transendothelial electrical resistance ; VE-cadherin ; vascular endothelial cadherin ; XPerT ; express permeability testing assay
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：28
- 期：6
- 页码：541-551
- 全文大小：3610 K
文摘
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Barrier-protective and and barrier-disruptive agonists induce different patterns of focal adhesion remodeling.
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Knockdown of vinculin attenuated both, OxPAPC-induced decrease and thrombin-induced increase in endothelial permeability.
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Vinculin at focal adhesions and adherens junctions transmits cytoskeletal tension and defines endothelial barrier response.