Hepatitis C virus infection upregulates expression of the type I interferon receptor in human peripheral blood mononuclear cells

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• 作者：Ren ; Fenyu ; Hino ; Keisuke ; Yamaguchi ; Yuhki ; Okazaki ; Muneko ; Kitase ; Akira ; Satoh ; Yasuhiro ; et. al.
• 关键词：HCV RNA ; IFNAR1 ; IFNAR2 ; Interferon-γ ; CD4⁺ T cells ; CD8⁺ T cells
• 刊名：Hepatology Research
• 出版年：2003
• 出版时间：May, 2003
• 年：2003
• 卷：26
• 期：1
• 页码：15-22
• 全文大小：331 K

文摘

To assess whether hepatitis C virus infection (HCV) affects type I interferon (IFN) receptor expression, the expression levels of two subunits of this receptor, IFNAR1 and IFNAR2, in peripheral blood mononuclear cells (PBMCs) were determined by flow-cytometric assay in 68 anti-HCV antibody-positive patients (47 positive for HCV RNA and 21 negative for HCV RNA) and 14 healthy controls. The percentages of IFNAR1- and IFNAR2-expressing cells were significantly higher in HCV RNA-positive patients than in HCV RNA-negative patients or healthy controls. In multiple regression analysis, the presence of HCV RNA in serum was independently associated with the expression of both IFNAR1 and IFNAR2 in PBMCs (P