Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response
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- 作者：Lin-Lin Maa ; Hui-Qiang Wanga ; Ping Wub ; Jin Hua ; Jin-Qiu Yina ; Shuo Wua ; Miao Gea ; Wen-Fang Suna ; Jiang-Yu Zhaoc ; Haji Akber Aisac ; Yu-Huan Lia ; yuhuanlibj@126.com" class="auth_mail" title="E-mail the corresponding author ; Jian-Dong Jianga ; b ; Jiang.jdong@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：IAV ; influenza A virus ; HO-1 ; heme oxygenase-1 ; Nrf2 ; erythroid 2-related factor 2 ; ISGs ; IFN-stimulated genes ; RdRp ; RNA-dependent RNA polymerase ; TLRs ; toll-like receptors ; RLR ; RIG-I-like receptors ; MKP5 ; MAPK phosphatase 5 ; IRF3 ; interferon regulatory factor 3 ; HIV ; human immunodeficiency virus ; HCV ; hepatitis C virus ; HBV ; hepatitis B virus ; EBOV ; Ebola virus ; OC ; oseltamivir carboxylate ; AH ; amantadine hydrochloride ; RBV ; ribavirin ; OP ; oseltamivir phosphate ; MRC-5 ; human fetal lung fibrob
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：347-361
- 全文大小：5885 K
文摘
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Rupestonic acid derivative YZH-106 inhibits the replication of influenza virus through up-regulating HO-1.
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HO-1 induces the expression of type I IFNs possibly independent of its enzymatic activities.
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HO-1 might be a promising host target for antiviral therapeutics against influenza and other viral infectious diseases.