Redox-coupled structural changes of the catalytic a鈥?domain of protein disulfide isomerase
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- 作者：Koya Inagakia ; b ; Tadashi Satoha ; c ; Maho Yagi-Utsumia ; b ; Anne-Charlotte Le Gullucheb ; Takahiro Anzaia ; b ; Yoshinori Uekusaa ; b ; Yukiko Kamiyaa ; b ; Koichi Katoa ; b ; kkatonmr@ims.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANS ; 8-anilino-1-naphthalenesulfonic acid ; DTT ; dithiothreitol ; MD ; molecular dynamics ; PDI ; protein disulfide isomerase
- 刊名：FEBS Letters
- 出版年：2015
- 出版时间：14 September 2015
- 年：2015
- 卷：589
- 期：19
- 页码：2690-2694
- 全文大小：1025 K
文摘
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Solution structure of a′-domain of PDI was determined in its oxidized state.
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Structural changes of the b′-domain interface occurred between its redox states.
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Insight into the redox-coupled domain rearrangement mechanism was provided.