Systemic administration of resveratrol suppress the nociceptive neuronal activity of spinal trigeminal nucleus caudalis in rats
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- 作者：Shiori Takehanaa ; Kenta Sekiguchia ; Maki Inoueb ; Yoshiko Kubotac ; Yukihiko Itoc ; Kei Yuic ; Yoshihito Shimazua ; Mamoru Takedaa ; m-takeda@azabu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：SpVc ; trigeminal spinal nucleus caudalis ; WDR ; wide dynamic range ; CAM ; complementary and alternative medicine ; TRP ; transient receptor potential ; TRPA1 ; TRP ankyrin 1 ; DRG ; dorsal root ganglion ; ANOVA ; analysis of variance ; PAG ; periaqueductal gray ; 5-HT3 receptor ; 5-hydroxytrypytamine type 3 receptor
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：117-122
- 全文大小：963 K
文摘
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Intravenous resveratrol administration suppress trigeminal WDR neuronal excitability.
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Suppressive effect of resveratrol was dose-dependent and reversible manner.
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Magnitude of inhibition was significantly greater for noxious than non-noxious stimulation.
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Resveratrol contributes to CAM therapeutic agents for trigeminal nociception without side effect.