Learned helplessness activates hippocampal microglia in rats: A potential target for the antidepressant imipramine

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• 作者：Masaaki Iwata^a ; Hisahito Ishida^a ; Koichi Kaneko^a ; Yukihiko Shirayama^b ; ^{shirayama@rapid.ocn.ne.jp}
• 关键词：Learned helplessness ; Depression ; Hippocampus ; Microglia ; Antidepressants
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：150-151
• 期：Complete
• 页码：138-146
• 全文大小：1667 K
• 卷排序：150

文摘

Numbers of activated microglia were increased in the hippocampus of LH rats. Administering imipramine to these rats decreased the number of activated microglia. Antidepressant treatments had no effect on activated cell numbers in naïve rats.