Celecoxib could reverse the hypoxia-induced Angiopoietin-2 upregulation in gastric cancer

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• 作者：Jun Wang ; Kaichun Wu ; Feihu Bai ; Huihong Zhai ; Huahong Xie ; Yulei Du ; Jie Liang ; Shuang Han ; Yu Chen ; Tao Lin and Daiming Fan
• 刊名：Cancer Letters
• 出版年：2006
• 出版时间：8 October 2006
• 年：2006
• 卷：242
• 期：1
• 页码：20-27
• 全文大小：294 K

文摘

We investigated the potential effect of Cyclooxygenase-2 (Cox-2) on hypoxia-induced Angiopoietin-2 (Ang-2) expression in gastric cancer cells. Our results revealed that hypoxia augmented Cox-2 and Ang-2 expressions. Also, the hypoxia-induced Ang-2 could be mimicked by CoCl₂ treatment while genestein treatment could partially counteract the hypoxia-induced Ang-2 expression. Celecoxib but not Cox-1 inhibitor sc-560 reversed the hypoxia-induced Ang-2 expression, while this effect could be partially restored by addition of exogenous PGE2. Our findings suggest that the hypoxia-elevated Ang-2 expression in gastric cancer cells may be mediated by both Cox-2-derived PGE2 and HIF-1α pathways, while celecoxib could counteract the hypoxia-induced Ang-2 expression.