Staphylococcus aureus induces TGF-β1 and bFGF expression through the activation of AP-1 and NF-κB transcription factors in bovine mammary gland fibroblasts
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- 作者：Jianmei Wu1 ; Yulin Ding1 ; Yannan Bi1 ; Yi Wang ; Yu Zhi ; Jinling Wang ; Fenglong Wang ; 1 ; fengloowang@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Staphylococcus aureus ; Bovine mammary fibroblast ; TLR&ndash ; NF-κB ; TLR&ndash ; AP-1 ; TGF-β1 ; bFGF
- 刊名：Microbial Pathogenesis
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：7-14
- 全文大小：1767 K
文摘
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S. aureus upregulated TGF-β1 and bFGF mRNA expression and secretion.
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S.aureus increased the mRNA and protein expression of TLR2 and TLR4.
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S. aureus increased the protein expression of p-NF-κB and p-c-jun.
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The increase in TGF-β1 and bFGF expression was shown to be inhibited by AP-1- and NF-κB-specific inhibitors.