Alcohol reduces insulin–hypertension relationship in a general population The Hisayama study
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- 作者：Arima ; Hisatomi ; Kiyohara ; Yutaka ; Kato ; Isao ; Tanizaki ; Yumihiro ; Kubo ; Michiaki ; Iwamoto ; Hiromitsu ; et. al.
- 关键词：Hypertension ; Insulin ; Insulin resistance ; Alcohol ; Prospective studies ; Incidence
- 刊名：Journal of Clinical Epidemiology
- 出版年：2002
- 出版时间：September, 2002
- 年：2002
- 卷：55
- 期：9
- 页码：863-869
- 全文大小：107 K
文摘
Insulin resistance may be a factor in the etiology of hypertension, and habitual alcohol intake may modify this relationship. We prospectively examined this hypothesis in 1,133 nonhypertensive, nondiabetic Japanese subjects, aged 40–79 years. Alcohol drinkers were more frequent among men than women at baseline (57.7 vs. 8.2 % ). The age-adjusted incidence of hypertension significantly increased with the elevating baseline insulin levels in women (P = .003 for trend), but not in men. The age- and sex-adjusted insulin levels and insulin resistance index decreased with elevating alcohol intake, while fasting glucose levels remained unchanged, suggesting that alcohol improves insulin sensitivity. Among nondrinkers, the age-adjusted incidence of hypertension significantly increased with elevating insulin tertiles in both sexes (P = .048 and .002 for trend in men and women, respectively), but not among drinkers. Our findings suggest a close association between insulin resistance and the incidence of hypertension in Japanese. However, alcohol modified and reduced this relationship.