- 作者：Jun Hata ; Yasufumi Doi ; Toshiharu Ninomiya ; Yumihiro Tanizaki ; Koji Yonemoto ; Masayo Fukuhara ; Michiaki Kubo ; Takanari Kitazono ; Mitsuo Iida ; Yutaka Kiyohara
- 关键词：Metabolic syndrome ; Ischemic stroke ; Epidemiology ; Risk factors ; Stroke classification
- 刊名：Atherosclerosis
- 出版年：2010
- 出版时间：May 2010
- 年：2010
- 卷：210
- 期：1
- 页码：249-255
- 全文大小：148 K
ObjectiveWe evaluated the impact of metabolic syndrome (MetS) defined by various criteria on the occurrence of ischemic stroke subtypes in a general Japanese population.Methods
A total of 2452 residents of a Japanese community, Hisayama, aged 40 years or older, were followed up for 14 years. To define MetS, we used the original Japanese criteria, the modified Japanese criteria, the International Diabetes Federation (IDF) criteria, the original National Cholesterol Education Program's Adult Treatment Panel III (NCEP) criteria, and the modified NCEP criteria. We substituted a waist circumference of ≥90 cm in men and ≥80 cm in women for the values of ≥85 cm and ≥90 cm, respectively, in the modified Japanese criteria and for >102 cm and >88 cm, respectively, in the modified NCEP criteria.
Results
Only MetS defined by the modified Japanese criteria showed a significant association with the development of lacunar infarction, and its hazard ratios (HRs) for the development of atherothrombotic and cardioembolic infarction were significant and greater than those of MetS defined by the other criteria: adjusted HRs for lacunar, atherothrombotic and cardioembolic infarction were 1.94 (95 % confidence interval (CI), 1.13–3.32; P = 0.02), 2.55 (95 % CI, 1.25–5.18; P = 0.01) and 3.94 (95 % CI, 1.89–8.22, P < 0.001), respectively, after adjustment for confounding factors.
Conclusion
Our findings suggest that MetS defined by the Japanese criteria with the modification of a waist circumference of ≥90 cm in men and ≥80 cm in women is a better predictor of each ischemic stroke subtype in the Japanese population.