DHA-PC and DHA-PS improved Aβ1-40 induced cognitive deficiency uncoupled with an increase in brain DHA in rats
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- 作者：Min Wen ; Lin Ding ; Lingyu Zhang ; Miaomiao Zhou ; Jie Xu ; Jingfeng Wang ; Yuming Wang ; wangyuming@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Changhu Xue ; xuech@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer's disease ; Aβ1&ndash ; 40 ; DHA-PLs ; Inflammation ; Hyper-phosphorylated tau ; Apoptosis
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：22
- 期：Complete
- 页码：417-430
- 全文大小：1713 K
文摘
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DHA-PS has more significant effect on Aβ-induced cognitive deficiency than DHA-PC.
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DHA-PLs improved Aβ-induced brain dysfunction uncoupled with brain DHA increase.
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The mechanism of DHA-PLs involved in ameliorating Aβ induced oxidative stress, inflammation cascade and Tau pathology.
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The effect of DHA-PLs on Aβ-induced cognitive deficiency is closely related with the polar group of phospholipid.