The relationship between body weight and inflammation: Lesson from anti-TNF-α antibody therapy

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• 作者：Ilaria Peluso^a ; Maura Palmery^b ; ^{maura.palmery@uniroma1.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：HDL ; high density lipoproteins ; HOMA ; Homeostasis Model of Assessment ; IL ; interleukin ; IFN ; interferon ; LDL ; low density lipoproteins ; M1 ; pro-inflammatory-activated macrophages ; Th ; T helper ; TNF ; Tumor Necrosis Factor ; Treg ; regulatory T cells
• 刊名：Human Immunology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：77
• 期：1
• 页码：47-53
• 全文大小：765 K

文摘

Obesity is associated with many pathological conditions. Tumor Necrosis Factor-α (TNF-α) is one of the key mediators of inflammation involved in the obesity-related insulin resistance development. We aim to review the human evidence useful to clarify the relationship between inflammation and body weight, with particular reference to TNF-α. Genetic polymorphisms and epigenetic factors, such as diet, could affect TNF-α activity. TNF-α is associated with obesity, but also with anorexia and cachexia. Despite the role of TNF-α in obesity-related diseases, anti-TNF-α antibody therapy is associated with an increase in adiposity. In conclusion the reviewed results suggest that inflammation is more likely a consequence rather than a cause of obesity.