RNA interference targeting CYP76AH1 in hairy roots of Salvia miltiorrhiza reveals its key role in the biosynthetic pathway of tanshinones
详细信息 查看全文
- 作者：Ying Maa ; b ; xiaoma1110@126.com" class="auth_mail" title="E-mail the corresponding author ; Xiao-Hui Mab ; c ; maxiaohui1988@126.com" class="auth_mail" title="E-mail the corresponding author ; Fan-Yun Menga ; mfy@bnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhi-Lai Zhanb ; zzlzhongyi@163.com" class="auth_mail" title="E-mail the corresponding author ; Juan Guob ; guojuanzy@163.com" class="auth_mail" title="E-mail the corresponding author ; Lu-Qi Huangb ; huangluqi01@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tanshinones ; Salvia miltiorrhiza ; Biosynthetic pathway ; RNAi ; Cytochrome P450
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：19 August 2016
- 年：2016
- 卷：477
- 期：2
- 页码：155-160
- 全文大小：738 K
文摘
- •
A CYP76AH1 RNAi system for Danshen hairy roots is constructed.
- •
The in vivo catalytic activity of CYP76AH1 is revealed by RNAi system.
- •
The RNAi system verified the key role of CYP76AH1 in the biosynthesis of tanshinones.
- •
CYP76AH1 could be used as a target for metabolic engineering.