Protective role of apigenin in cisplatin-induced renal injury

详细信息    查看全文

• 作者：Xuexiu He¹ ; Chunmei Li¹ ; Zhengkai Wei ; Jingjing Wang ; Jinhua Kou ; Weijian Liu ; Mingyu Shi ; Zhengtao Yang ; Yunhe Fu ; ^{fuyunhesky@sina.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cisplatin ; Kidney ; Apigenin ; Oxidative stress ; Inflammation
• 刊名：European Journal of Pharmacology
• 出版年：2016
• 出版时间：15 October 2016
• 年：2016
• 卷：789
• 期：Complete
• 页码：215-221
• 全文大小：1552 K

文摘

This study aimed to investigate the effects and molecular mechanisms of the effects of apigenin on cisplatin (CP)-induced kidney injury in mice. Apigenin was intraperitoneally administered for 3 consecutive days before CP treatment. We found that apigenin pretreatment significantly attenuated the damage to the kidneys and decreased the levels of serum creatinine, blood urea nitrogen (BUN), glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD), which were increased by CP. Apigenin significantly decreased the levels of TNF-α, IL-1β and TGFβ in the kidneys. Additionally, apigenin inhibited the activations of CYP2E1, phospho-NF-κB p65 and phospho-P38 MAPK in CP-induced renal injury. These results suggest that the renoprotective effects of apigenin may be related to the suppressions of oxidative stress and inflammation in CP-induced renal injury in mice.