1H NMR spectroscopic evidence of interaction between ibuprofen and lipoproteins in human blood plasma
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- 作者：Yang ; Yunhuang ; Bai ; Guoyun ; Zhang ; Xu ; Ye ; Chaohui ; Liu ; Maili
- 关键词：Nuclear magnetic resonance ; Ibuprofen ; Lipoproteins ; Unsaturated lipids ; Phosphatidylcholine ; Sphingomyelin
- 刊名：Analytical Biochemistry
- 出版年：2004
- 出版时间：January 15, 2004
- 年：2004
- 卷：324
- 期：2
- 页码：292-297
- 全文大小：327 K
文摘
Recent studies have suggested that ibuprofen inhibits low-density lipoprotein oxidation in a high dose-dependent manner and is a promising drug for treatment of the conditions associated with atherosclerosis. In this article, we present the NMR spectroscopic evidence for the interaction between ibuprofen and phospholipids in lipoprotein particles in intact human plasma. Ibuprofen caused chemical shift upfield drifts for the protons of –N+(CH3)3 moieties of phosphatidylcholine and sphingomyelin, olefinic chains (–CH
CH–, –CHCHCH2CHCH–, –(CH2)nCH2CH), and (CH2)n and CH3 groups, from unsaturated lipids in lipoprotein particles. The ibuprofen may interact directly with the above-mentioned groups of phospholipids or induce structural changes in the lipoproteins. This may shed light on the mechanism by which the drug protects against oxidative modification of lipoproteins.
CH–, –CHCHCH2CHCH–, –(CH2)nCH2CH), and (CH2)n and CH3 groups, from unsaturated lipids in lipoprotein particles. The ibuprofen may interact directly with the above-mentioned groups of phospholipids or induce structural changes in the lipoproteins. This may shed light on the mechanism by which the drug protects against oxidative modification of lipoproteins.