Microstructural constitutive model of active coronary media

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• 作者：Huan Chen ; Tong Luo ; Xuefeng Zhao ; Xiao Lu ; Yunlong Huo ; Ghassan S. Kassab
• 关键词：Biaxial vasoactivity ; Vascular smooth muscle cell ; Deformation ; Morphology ; Coronary artery
• 刊名：Biomaterials
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：34
• 期：31
• 页码：7575-7583
• 全文大小：2384 K

文摘

Although vascular smooth muscle cells (VSMCs) are pivotal in physiology and pathology, there is a lack of detailed morphological data on these cells. The objective of this study was to determine dimensions (width and length) and orientation of swine coronary VSMCs and to develop a microstructural constitutive model of active media. The dimensions, spatial aspect ratio and orientation angle of VSMCs measured at zero-stress state were found to follow continuous normal (or bimodal normal) distributions. The VSMCs aligned off circumferential direction of blood vessels with symmetrical polar angles 18.7¡ã?¡À?10.9¡ã, and the local VSMC deformation was affine with tissue-level deformation. A microstructure-based active constitutive model was developed to predict the biaxial vasoactivity of coronary media, based on experimental measurements of geometrical and deformation features of VSMCs. The results revealed that the axial active response of blood vessels is associated with multi-axial contraction as well as oblique VSMC arrangement. The present morphological database is essential for developing accurate structural models and is seminal for understanding the biomechanics of muscular vessels.