The effects of MCC-134 on the ATP-sensitive K⁺ channels in pig urethra

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• 作者：Yunoki ; Takakazu ; Teramoto ; Noriyoshi ; Takano ; Naruaki ; Seki ; Narihito ; Creed ; Kate E. ; Naito ; Seiji ; et. al.
• 关键词：K⁺ channel ; ATP-sensitive ; MCC-134 ; Sulphonylurea receptor ; Urethra ; Smooth muscle
• 刊名：European Journal of Pharmacology
• 出版年：2003
• 出版时间：December 15, 2003
• 年：2003
• 卷：482
• 期：1-3
• 页码：287-295
• 全文大小：309 K

文摘

We have investigated the effects of MCC-134 (1-[4-(1H-imidazol-1-yl)benzoyl]-N-methyl-cyclobutanecarbothioamide) on membrane currents and ATP-sensitive K⁺ channel (K_ATP channel) opener-induced currents in pig urethra by use of patch-clamp techniques (conventional whole-cell configuration and nystatin perforated patch recordings). Tension measurement was also performed to study the effects of MCC-134 on the resting tone of pig urethral strips. MCC-134 reduced the resting tone of pig urethra in a concentration-dependent manner (EC₅₀