ZIP restores estrogen receptor expression and response to Tamoxifen in estrogen receptor negative tumors
详细信息 查看全文
- 作者：Ning Zhua ; Jing Zhangb ; Xiaodong Qinb ; Ruidong Miaoa ; Yuping Dua ; Jinbo Yanga ; yangjb@lzu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ZIP ; ER-negative ; Tamoxifen ; In vivo
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：25 November 2016
- 年：2016
- 卷：480
- 期：4
- 页码：570-573
- 全文大小：803 K
文摘
- •
ZIP expression was higher in primary breast tumor cells than in progressed cells.
- •
ZIP restored Tamoxifen sensitivity in ER-negative breast tumor cells.
- •
ZIP repressed EGFR expression and elevated ERalpha expression in ER-negative breast cells.
- •
ZIP repressed AKT-mTOR activities.
- •
ZIP enhanced Tamoxifen response in ER-negative breast tumor xenografts.