Corneal transparency: Genesis, maintenance and dysfunction

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• 作者：Yureeda Qazi ; Gilbert Wong ; Bryan Monson ; Jack Stringham ; Balamurali K. Ambati
• 关键词：Corneal neovascularization ; Corneal angiogenesis ; Corneal transplant ; VEGF ; Flt-1 ; Flk ; Corneal haze ; Corneal lymphangiogenesis ; PRK ; PDT ; HLA typing
• 刊名：Brain Research Bulletin
• 出版年：2010
• 出版时间：15 February 2010
• 年：2010
• 卷：81
• 期：2-3
• 页码：198-210
• 全文大小：268 K

文摘

Optimal vision is contingent upon transparency of the cornea. Corneal neovascularization, trauma and, surgical procedures such as photorefractive keratectomy and graft rejection after penetrating keratoplasty can lead to corneal opacification. In this article we identify the underlying basis of corneal transparency and factors that compromise the integrity of the cornea. With evidence from work on animal models and clinical studies, we explore the molecular mechanisms of both corneal avascularity and its dysfunction. We also seek to review therapeutic regimens that can safely salvage and restore corneal transparency.