A retrospective evaluation method for in vitro mammalian genotoxicity tests using cytotoxicity index transformation formulae
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- 作者：Yurika Fujita ; Toshio Kasamatsu ; Naohiro Ikeda ; Naohiro Nishiyama ; Hiroshi Honda ; honda.hiroshi@kao.co.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：CA ; chromosomal aberration ; DB ; database ; ECVAM ; The European Centre for the Validation of Alternative Methods ; IWGT ; International Workshops on Genotoxicity Testing ; JEC ; Japan Existing Chemical ; LOGEL ; lowest observed genotoxicity effect level ; MN ; micronucleus ; OECD ; Organization for Economic Co-operation and Development ; RCC ; relative cell count ; RICC ; relative increase in cell count ; RPD ; relative population doubling ; PD ; population doubling ; TG ; test guideline
- 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：796
- 期：Complete
- 页码：1-7
- 全文大小：427 K
文摘
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New mammalian cell genotoxicity test guidelines recommend new cytotoxicity indices.
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We established formulae to estimate new cytotoxicity indices from previous results.
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Previous results were evaluated using the new formulae for cytotoxicity indices.
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Almost half the reported false–positive results were judged as possibly negative.
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Our methods facilitate retrospective review of mammalian cell genotoxicity data.