A bis-malonic acid fullerene derivative significantly suppressed IL-33-induced IL-6 expression by inhibiting NF-κB activation
详细信息 查看全文
- 作者：Megumi Funakoshi-Tagoa ; tago-mg@pha.keio.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yurika Miyagawaa ; Fumihito Uedaa ; Tadahiko Mashinoa ; Yasuhiro Moriwakia ; Kenji Tagob ; Tadashi Kasaharaa ; Hiroomi Tamuraa
- 关键词：BMMC ; bone marrow-derived mast cells ; BSA ; bovine serum albumin ; CARMA 3 ; CARD-containing MAGUK protein 3 ; DMSO ; dimethyl sulfoxide ; FBS ; fetal bovine serum ; IκBα ; inhibitor of NF-kappaB ; IKK ; IκB kinase ; IL ; interleukin ; IL-1R ; interleukin 1 receptor ; IL-1RAcP ; IL-1R accessory protein ; IRAK-1 ; IL-1R-associated kinase-1 ; JNK ; c-Jun. N-terminal kinase ; LPA ; lysophosphatidic acid ; MAP kinase ; mitogen-activated protein kinase ; MEKK1 ; MEK kinase 1 ; MyD88 ; myeloid differentiation factor 88 ; NF-κB ; nu
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：254-264
- 全文大小：2436 K
文摘
- •
A bis-malonic acid fullerene derivative inhibits the IL-33-induced IL-6 expression.
- •
A bis-malonic acid fullerene derivative inhibits the IL-33-induced NF-κB activation.
- •
A bis-malonic acid fullerene derivative directly inhibits IKK activation.