Transient ischemia-reperfusion in the hand and foot elicits spontaneous dysesthesia.
We established a mouse model of hind-paw transient ischemic-reperfusion.
In this model, peripheral nerve activity and lipid peroxidation were increased.
An antioxidant reagent countered both the nerve activity and lipid peroxidation.
Both oxidative stress and nerve activity may contribute to peripheral dysesthesia.