Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats

详细信息    查看全文

• 作者：&#xd6 ; zgü ; r Devrim Can^a ; ^{ozgurdt@anadolu.edu.tr"" rel=""nofollow} ; Yusuf &#xd6 ; ztü ; rk^a ; Nilgü ; n &#xd6 ; ztü ; rk^b ; Gianni Sagratini^c ; Massimo Ricciutelli^c ; Sauro Vittori^c ; Filippo Maggi^c
• 关键词：St. John's Wort ; Hypericum perforatum ; Diabetes mellitus ; Rutin ; Tail pinch ; Tail flick
• 刊名：Fitoterapia
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：82
• 期：4
• 页码：576-584
• 全文大小：962 K

文摘

This present study was undertaken to examine treating effects of St. John's Wort (SJW) extract on nociceptive perception of STZ-diabetic animals based on its potential antidiabetic and antinociceptive activities. One week administrations of SJW extract (125 and 250 mg/kg) induced significant decrease in high blood glucose levels of three weeks STZ-diabetic rats and improved their dysregulated metabolic parameters. In addition, SJW extract treatment caused restoration in the mechanical hyperalgesia of diabetic animals. These findings provide a rationale for the traditional use of SJW against diabetes and display the potential of this plant as a new drug candidate/source for the treatment of diabetic pain.