Prevention of Contrast-Induced Nephropathy by Bolus Injection of Sodium Bicarbonate in Patients With Chronic Kidney Disease Undergoing Emergent Coronary Procedures

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• 作者：Hiromichi Ueda MD^a ; ^{u_hiromichi@yahoo.co.jp} ; Takahisa Yamada MD ; PhD^a ; Masaharu Masuda MD^a ; Yuji Okuyama MD ; PhD^a ; Takashi Morita MD ; PhD^a ; Yoshio Furukawa MD ; PhD^a ; Tanaka Koji MD^a ; Yusuke Iwasaki MD^a ; Takeshi Okada MD^a ; Masato Kawasaki MD^a ; Yuki Kuramoto MD^a ; Takashi Naito MD^a ; Tadao Fujimoto MD^a ; Issei Komuro MD ; PhD^b ; Masatake Fukunami MD ; PhD^a
• 刊名：The American Journal of Cardiology
• 出版年：2011
• 出版时间：15 April 2011
• 年：2011
• 卷：107
• 期：8
• 页码：1163-1167
• 全文大小：417 K

文摘

We conducted a prospective study to determine whether a bolus injection of sodium bicarbonate before emergent coronary procedures in patients with chronic kidney disease (CKD) might prevent contrast-induced nephropathy (CIN). We enrolled 59 patients with CKD, defined by a serum creatinine concentration of >1.1 mg/dl or an estimated glomerular filtration rate of <60 ml/min, who were scheduled at admission to undergo an emergent coronary procedure. The patients were randomized to receive a bolus intravenous injection of 154 mEq/L of sodium bicarbonate (n = 30) or sodium chloride (n = 29) at the dose of 0.5 ml/kg, before contrast administration, followed by infusion of 154 mEq/L sodium bicarbonate at 1 ml/kg/hour for 6 hours in both groups. The primary end point was the occurrence of CIN, defined as an increase by >25 % or >0.5 mg/dl of the serum creatinine level within 2 days after the procedure. In the sodium bicarbonate group, the serum creatinine concentration remained unchanged within 2 days of contrast administration (from 1.32 ± 0.46 to 1.38 ± 0.60 mg/dl, p = 0.33). In contrast, it had increased in the sodium chloride group (1.51 ± 0.59 to 1.91 ± 1.19 mg/dl, p = 0.006). The incidence of CIN was significantly lower in the sodium bicarbonate group than in the sodium chloride group (3.3 % vs 27.6 % , p = 0.01). In conclusion, rapid alkalization by bolus injection of sodium bicarbonate was effective for the prevention of CIN in patients with CKD undergoing emergent procedures.