Pathogenic memory type Th2 cells in allergic inflammation

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• 作者：Yusuke Endo ; Kiyoshi Hirahara ; Ryoji Yagi ; Damon J. Tumes ; Toshinori Nakayama
• 关键词：pathogenic T cells ; memory Th2 diversity ; IL-5 ; ILC2 ; asthma
• 刊名：Trends in Immunology
• 出版年：February, 2014
• 年：2014
• 卷：35
• 期：2
• 页码：69-78
• 全文大小：915 K

文摘

Immunological memory is a hallmark of adaptive immunity. Memory CD4 T helper (Th) cells are central to acquired immunity, and vaccines for infectious diseases are developed based on this concept. However, memory Th cells also play a critical role in the pathogenesis of various chronic inflammatory diseases, including asthma. We refer to these populations as 鈥榩athogenic memory Th cells.鈥?Here, we review recent developments highlighting the functions and characteristics of several pathogenic memory type Th2 cell subsets in allergic inflammation. Also discussed are the similarities and differences between pathogenic memory Th2 cells and recently identified type 2 innate lymphoid cells (ILC2), focusing on cytokine production and phenotypic profiles.