The study examined 518 native Japanese male patients with sporadic prostate cancer. Germline DNA samples were obtained from all participants and genotyping of rs6983561was performed using a TaqMan assay. Observation periods were from the date of diagnosis of prostate cancer to May 21, 2010. The Cox proportional hazards model was used to estimate the cause-specific survival (CSS) and the overall survival (OS).
Patients with the CA/CC genotype of rs6983561 survived significantly longer than those with the AA genotype. In a multivariate model, the hazard ratios (HRs) and 95 % confidence intervals (CIs) of the CSS and the OS for the rs6983561 polymorphism were 2.438 (1.262 ?5.046, P = .007) and 1.957 (1.142 ?3.485, P = .014), respectively. When the analysis was restricted to subjects with metastatic disease, the HRs of the CSS and the OS were 3.353 (95 % CI, 1.689 ?7.446; P = 3.76 x 10-4) and 3.361 (95 % CI, 1.741 ?7.136; P = 1.70 x 10-4), respectively.
In the Japanese population examined in this study, the rs6983561 polymorphism at 8q24 was significantly associated with prostate cancer mortality, especially among patients with metastatic disease.