• 作者：Jinxing Xia^a ; ^c ; Zheng Hu^a ; ^b ; Satoshi Yoshihara^a ; Yuying Li^a ; ^b ; Chun-Hui Jin^a ; ^b ; Shulian Tan^a ; ^b ; Wei Li^b ; Qingfeng Chen^d ; ^e ; Megan Sykes^a ; Yong-Guang Yang^a ; ^b ; ^{yy2324@columbia.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Humanized mice ; Leukemia ; Lymphopenia ; Mixed-lineage leukemia fusion gene ; Recipient leukocyte infusion
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：10
• 期：Complete
• 页码：101-108
• 全文大小：1281 K

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NSG mice grafted with thymus/oncogenic HSC develop human immune system and leukemia.

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Leukemia transfer to mice with autologous immunity suffices to model immunotherapy.

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Lymphopenia enhances RLI-mediated HVGR and anti-leukemia activity in mixed chimeras.

This study establishes a humanized mouse model with human immunity and autologous leukemia. Using this model, the authors demonstrate that lymphopenia promotes the rejection of donor hematopoietic chimerism and the associated anti-leukemia response by recipient leukocyte infusion in mixed allogeneic chimeras.