Serum levels of sex steroids and metabolites following 12 weeks of intravaginal 0.50% DHEA administration
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- 作者：Yuyong Kea ; Fernand Labriea ; fernand.labrie@endoceutics.com" class="auth_mail" title="E-mail the corresponding author ; Renaud Gonthiera ; Jean-Nicolas Simarda ; Danielle Bergerona ; Cé ; line Martela ; Mario Vaillancourta ; Marlene Montesinoa ; Lyne Lavoiea ; David F. Archerb ; John Balserc ; Erick Moyneurd ; ; other participating Members of the Prasterone Clinical Research Group participating Members of the Prasterone Clinical Research Group
- 关键词：Liquid chromatography tandem mass spectrometry ; Intracrinology ; Menopause ; dehydroepiandrosterone ; Prasterone ; Vulvovaginal atrophy
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：154
- 期：Complete
- 页码：186-196
- 全文大小：1879 K
文摘
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Intravaginal 0.50% DHEA was administered daily for 12 weeks in postmenopausal women with VVA.
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Eleven steroids were measured in serum by validated mass spectrometry-based assays.
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All serum sex steroids remained well within normal postmenopausal values, thus excluding systemic exposure.
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At 12 weeks, serum estradiol was 22% below average normal postmenopausal values.
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Such data are in line with the physiology of sex steroids after menopause or midlife gynecological symptoms.