We generated a gE/gI/TK-deleted mutant rPRVTJ-delgE/gI/TK based on a PRV variant.
rPRVTJ-delgE/gI/TK displayed higher safety than rPRVTJ-delgE/gI in susceptible animals.
rPRVTJ-delgE/gI/TK induced antibodies and protection comparable to rPRVTJ-delgE/gI.