Hematopoietic Cell Transplantation Outcomes in Monosomal Karyotype Myeloid Malignancies
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- 作者：Marcelo C. Pasquini1 ; mpasquini@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Mei-Jie Zhang1 ; 2 ; Bruno C. Medeiros3 ; Philippe Armand4 ; Zhen-Huan Hu1 ; Taiga Nishihori5 ; Mahmoud D. Aljurf6 ; Gö ; rgü ; n Akpek7 ; Jean-Yves Cahn8 ; Mitchell S. Cairo9 ; Jan Cerny10 ; Edward A. Copelan11 ; Abhinav Deol12 ; Cé ; sar O. Freytes13 ; Robert Peter Gale14 ; Siddhartha Ganguly15 ; Biju George16 ; Vikas Gupta17 ; Gregory A. Hale18 ; Rammurti T. Kamble19 ; Thomas R. Klumpp20 ; Hillard M. Lazarus21 ; Selina M. Luger22 ; Jane L. Liesveld23 ; Mark R. Litzow24 ; David I. Marks25 ; Rodrigo Martino26 ; Maxim Norkin27 ; Richard F. Olsson28 ; 29 ; Betul Oran30 ; Attaphol Pawarode31 ; Michael A. Pulsipher32 ; Muthalagu Ramanathan10 ; Ran Reshef22 ; Ayman A. Saad33 ; Wael Saber1 ; Bipin N. Savani34 ; Harry C. Schouten35 ; Olle Ringdé ; n28 ; 36 ; Martin S. Tallman37 ; Geoffrey L. Uy38 ; William A. Wood Jr.39 ; Baldeep Wirk40 ; Waleska S. Pé ; rez1 ; Minoo Batiwalla41 ; Daniel J. Weisdorf42
- 关键词：Monosomal karyotype ; Acute myeloid leukemia ; Myelodysplastic syndrome ; Allogeneic transplantation
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：22
- 期：2
- 页码：248-257
- 全文大小：679 K
文摘
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Patients with monosomal karyotype acute myeloid leukemia have worse survival after transplantation compared with patients with other acute myeloid leukemia in first complete remission.
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Monosomal karyotype presence in patients with myelodysplastic syndrome has a negative prognostic impact after allogeneic transplantation.
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The negative impact of the presence of monosomal karyotype is observed after myeloablative and reduced-intensity conditioning.