Comparison of functional assays used in the clinical development of a placental malaria vaccine

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• 作者：Caroline Pehrson^a ; ^b ; ^{cpeh@sund.ku.dk} ; Kristine K. Heno^a ; ^b ; ^{kristineheno@hotmail.com} ; Yvonne Adams^a ; ^b ; ^{yadams@sund.ku.dk} ; Mafalda Resende^a ; ^b ; ^{mafaldaresende@gmail.com} ; Line Mathiesen^c ; ^{lima@sund.ku.dk} ; Max Soegaard^d ; ^{max@expres2ionbio.com} ; Willem A. de Jongh^d ; ^{wdj@expres2ionbio.com} ; Thor G. Theander^a ; ^b ; ^{thor@sund.ku.dk} ; Ali Salanti^a ; ^b ; ^{salanti@sund.ku.dk} ; Morten A. Nielsen^a ; ^b ; ^{mortenn@sund.ku.dk}
• 关键词：VAR2CSA ; Plasmodium falciparum ; Placental malaria ; Binding inhibition assay ; Vaccine development
• 刊名：Vaccine
• 出版年：2017
• 出版时间：23 January 2017
• 年：2017
• 卷：35
• 期：4
• 页码：610-618
• 全文大小：467 K
• 卷排序：35

文摘

Comparability of placental malaria vaccine potency assays was investigated. Results from different binding inhibition assays cannot be compared directly. Sera should be tested in a dilution series. The level of parasite binding avidity affects the antibody inhibition.