GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate
详细信息 查看全文
- 作者：Stephan C. Jahna ; Mohamed Hassan M. Solaymanb ; c ; Ryan J. Lorenzoa ; Taimour Langaeeb ; Peter W. Stacpooled ; e ; Margaret O. Jamesa ; mojames@ufl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：[Cl&minus ; ] ; chloride concentration ; DCA ; dichloroacetate ; ERK ; extracellular signal-regulated kinase ; GSTZ1 ; glutathione transferase Z1 ; HER2 ; human epidermal growth factor receptor 2 ; PDC ; pyruvate dehydrogenase complex ; PDK ; pyruvate dehydrogenase kinase ; VDAC ; voltage-dependent anion channel
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1860
- 期：6
- 页码：1202-1210
- 全文大小：1112 K
文摘
- •
GSTZ1, the enzyme responsible for metabolism of DCA is often misregulated in cancer.
- •
GSTZ1 is downregulated in hepatocellular carcinoma and upregulated in breast cancer.
- •
Expression of GSTZ1 provides resistance against dichloroacetate treatment.
- •
Chloride concentrations in tumors may differ dramatically from surrounding tissues.
- •
High chloride may exacerbate the resistance provided by GSTZ1.