Pharmacological strategy for overcoming opioid-induced ventilatory disturbances

详细信息    查看全文

• 作者：Satoko Kimura ; Akira Haji
• 关键词：BIMU8 ; (endo-N-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2 ; 3-dehydro-2-oxo-3 -(prop-2-yl)-1H-benzimidazole-1-carboxamide ; (+)BW3738U86 ; (+)-4-((伪-R)-伪-((2S ; 5R)-4-allyl-2 ; 5-dimethyl-1-piperazinyl)-3 -hydroxybenzyl)-N ; N-diethylbenzamide ; DAMGO ; D-Ala(2)-N-MePhe(4)-Gly-ol(5)-enkephalin ; DPDPE ; D-Pen(2) ; D-Pen(5)-enkephalin ; DPI-3290 ; (+)-3-((伪-R)-伪-((2S ; 5R)-4-allyl-2 ; 5-dimethyl-1-piperazinyl)-3 -hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide ; JNJ-20788560 ; 9-(8-azabicyclo[3.2.1]oct-3-ylidene)-
• 刊名：European Journal of Pharmacology
• 出版年：15 February, 2014
• 年：2014
• 卷：725
• 期：Complete
• 页码：87-90
• 全文大小：375 K

文摘

Opioids are among the most frequently used analgesics for treatment of severe pain. However, certain of their side-effects, particularly ventilatory disturbances, often restrict their use. Separation of analgesia from respiratory depression has long been a goal in the basic research and therapeutic use of opioids. This report briefly describes opioid-induced respiratory depression and possible pharmacological strategies to counteract this without affecting analgesia.