Alcohol drinking increases the dopamine-stimulating effects of ethanol and reduces D2 auto-receptor and group II metabotropic glutamate receptor function within the posterior ventral tegmental area of alcohol preferring (P) rats
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- 作者：Zheng-Ming Ding ; zding@iupui.edu" class="auth_mail" title="E-mail the corresponding author ; Cynthia M. Ingraham ; Zachary A. Rodd ; William J. McBride
- 关键词：Dopamine ; Ethanol ; Glutamate ; LY341495 ; Nucleus accumbens ; Sulpiride ; Ventral tegmental area
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：41-48
- 全文大小：1111 K
文摘
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Neuroadaptations were examined in the posterior ventral tegmental area following long-term alcohol drinking.
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Alcohol drinking increased the stimulating effects of ethanol on dopamine neurons in the posterior ventral tegmental area.
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Alcohol drinking down-regulated D2 auto-receptor function in the posterior ventral tegmental area.
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Alcohol drinking reduced the functional activity of group II mGlu auto-receptors in the posterior ventral tegmental area.