文摘
Insulin and insulin secretagogue users have poorer breast cancer (BC) outcomes. Estrogen receptor negative BC occurs more among insulin and secretagogues users. Insulin users have lower baseline C-peptide and elevated leptin, IL-6, TNF-α and CRP. C-peptide is inversely correlated with IL-1β and IL-1Ra among insulin users. IL-1β and adiponectin levels are directly correlated in insulin users only.