David Triggle: Research collaborations and scientific exchanges with the China Pharmaceutical University, Nanjing, China

详细信息    查看全文

• 作者：De-Zai Dai ; ^{dezaidai@vip.sina.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ion channels ; Heart ; Anti-arrhythmia ; Calcium modulating proteins
• 刊名：Biochemical Pharmacology
• 出版年：2015
• 出版时间：15 November 2015
• 年：2015
• 卷：98
• 期：2
• 页码：303-307
• 全文大小：1035 K

文摘

Over the period 1995–2012, David Triggle was a frequent visitor to the China Pharmaceutical University in Nanjing, China making many important contributions that enhanced the activities of the Research Division of Pharmacology at the University. In addition to providing collegial advice and facilitating interactions with the international pharmacological community, Professor Triggle's international reputation as a thought leader in the field of ion channel research and drug discovery provided important insights into the potential pathophysiological and therapeutic effects of targeting ion channels. This included the L-type calcium channel and the outward delayed rectified potassium currents of rapid (IKr) and slow (IKs) components in the myocardium. The Nanjing research team had been particularly interested in ion channel dysfunction in the context of cardiac arrhythmias, remodeling and drug discovery. With Professor Triggle's assistance, the relationship between an increase in ICa.L and other biological events including an enhancement of IKr and IKr currents, NADPH oxidase and endothelin receptor activation, down regulation of calcium modulating protein FKBP12.6, sarco/endoplasmic reticulum Ca²⁺ATPse (SERCA2A) and calsequens 2 (CASQ2), calcium leak at the diastole and endoplasmic reticulum stress, were evaluated and are discussed. Additionally, the organization of several international symposia was greatly enhanced by input from Professor Triggle as were the published research manuscripts in international pharmacology journals. During his association with the China Pharmaceutical University, Professor Triggle aided in enhancing the scientific standing of the Pharmacology department and was a highly effective ambassador for international research cooperation.