Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice
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- 作者：Chrysovalantou E. Xirouchaki1 ; Salvatore P. Mangiafico1 ; Katherine Bate ; Zheng Ruan ; Amy M. Huang ; Bing Wilari Tedjosiswoyo ; Benjamin Lamont ; Wynne Pong ; Jenny Favaloro ; Amy R. Blair ; Jeffrey D. Zajac ; Joseph Proietto ; Sofianos Andrikopoulos ; sof@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：gys1 ; Glucose tolerance ; Insulin sensitivity ; Muscle glucose uptake ; Exercise capacity ; Inducible muscle-specific knockout (KO) mice
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：5
- 期：3
- 页码：221-232
- 全文大小：2052 K
文摘
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Muscle-specific gys1 knockdown in adult mice results in 70% reduction in skeletal muscle glycogen levels.
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Muscle-specific gys1 knockdown leads to glucose intolerance and peripheral insulin resistance.
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Muscle glycogen depletion caused impaired performance, as well as fatigue development during exercise.