- 作者：Beatriz Tijero ; Juan Carlos G¨®mez Esteban ; Johanne Somme ; Ver¨®nica Llorens ; Elena Lezcano ; Ana Martinez ; Trinidad Rodr¨ªguez ; Koldo Berganzo ; Juan Jos¨¦ Zarranz
- 关键词：Parkinson's disease ; Autonomic disorders ; LRRK2 gene
- 刊名：Parkinsonism and Related Disorders
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：19
- 期：10
- 页码：906-909
- 全文大小：189 K
Introduction
The aim of this study was to compare autonomic function in PD symptomatic carriers of the LRRK2 mutations and idiopathic Parkinson's disease (iPD) patients.Material and methods
We studied 25 PD patients: 12 with the LRRK2 mutation (6 G2019S and 6 R1441G), and 13 with iPD. All patients underwent blood pressure and heart rate monitoring during head up tilt, Valsalva maneuver and deep breathing, along with recording of sympathetic skin response (SSR) and cardiac MIBG scintigraphy.
Results
Three of the patients with iPD and one of the LRRK2 carriers had orthostatic hypotension. Arterial pressure ¡°overshoot¡± during phase IV of Valsalva maneuver was less pronounced in patients with iPD. During passive tilt, LRRK2 carries had higher increase of blood pressure than iPD patients MIBG late myocardial/mediastinal uptake ratios were higher in LRRK2 mutation carriers (1.51?¡À?0.28 vs 1.32?¡À?0.25; p?<?0.05).
Discussion
Carriers of the LRRK2 mutation had less autonomic impairment than those with iPD as shown by higher cardiac MIBG uptake and a tendency to less impairment of autonomic non-invasive tests. It is important to carry out larger studies comparing the clinical, functional and pathological characteristics of these patients.