Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and osteogenesis in rabbit femoral head osteonecrosis
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- 作者：Lihong Fan drfan2140@163.com" class="auth_mail" title="E-mail the corresponding author ; Chen Zhang osteozhang@163.com" class="auth_mail" title="E-mail the corresponding author ; Zefeng Yu i.donot.knowname@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhibin Shi drshizhibin@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiaoqian Dang dangxiaoqian@vip.163.com" class="auth_mail" title="E-mail the corresponding author ; Kunzheng Wang ; drwangkunzheng@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hypoxia precondition ; Bone marrow mesenchymal stem cell ; Angiogenesis ; Osteogenesis ; Osteonecrosis
- 刊名：Bone
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：81
- 期：Complete
- 页码：544-553
- 全文大小：2820 K
文摘
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The function of BMMSC was impaired during steroid-related ONFH.
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Hypoxic preconditioning of BMMSCs provided an effective strategy for treatment of ONFH.
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The mechanism involves: enhanced growth factors releasing, stimulated angiogenesis and osteogenesis.