Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro

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• 作者：Beyzagul Polat^a ; Zekai Halici^b ; ^{hzekai@gmail.com} ; ^{hzekai@atauni.edu.tr} ; Elif Cadirci^b ; Emre Karakus^c ; Yasin Bayir^d ; Abdulmecit Albayrak^b ; Deniz Unal^e
• 关键词：Serotonin ; Liver injury ; Fibrosis ; Inflammation ; CCl4
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：Complete
• 页码：227-235
• 全文大小：2689 K
• 卷排序：43

文摘

5-HT7 receptors have modulatory function in the inflammatory fibrotic process. Agonism of 5-HT7 receptors has hepatoprotective effects against liver fibrosis. 5-HT7 agonist LP-44 might become a useful therapeutic target for fibrosis.